Repetitive transcranial magnetic stimulation activates specific regions in rat brain.
Ji RR; Schlaepfer TE; Aizenman CD; Epstein CM; Qiu D; Huang JC; Rupp F
Proc Natl Acad Sci U S A 1998 Dec 22;95(26):15635-40

Repetitive Transcranial Magnetic Stimulation (rTMS) Is A
Noninvasive Technique To Induce Electric Currents In The Brain.
Although RTMS Is Being Evaluated As A Possible Alternative To
Electroconvulsive Therapy For The Treatment Of Refractory
Depression, Little Is Known About The Pattern Of Activation
Induced In The Brain By RTMS. We Have Compared Immediate
Early Gene Expression In Rat Brain After RTMS And
Electroconvulsive Stimulation, A Well-established Animal Model
For Electroconvulsive Therapy. Our Result Shows That RTMS
Applied In Conditions Effective In Animal Models Of Depression
Induces Different Patterns Of Immediate-early Gene Expression
Than Does Electroconvulsive Stimulation. In Particular, RTMS
Evokes Strong Neural Responses In The Paraventricular Nucleus
Of The Thalamus (PVT) And In Other Regions Involved In The
Regulation Of Circadian Rhythms. The Response In PVT Is
Independent Of The Orientation Of The Stimulation Probe Relative
To The Head. Part Of This Response Is Likely Because Of Direct
Activation, As Repetitive Magnetic Stimulation Also Activates PVT
Neurons In Brain Slices.
*Electromagnetic Fields
*Genes, Fos




em Psiquiatría