[Poster Session III: Basic Neuropharmacology; Clinical Neuropharmacology; Clinical Neurophysiology][3.117] Cortical Excitability In Progressive Myoclonus Epilepsies: A Polygraphic And Transcranial Magnetic Stimulation Study
Franco Valzania, Antonio Strafella, Andrea Tropeani, Stefania Nassetti, Guido Rubboli, Carlo A. Tass

To Investigate Cortical Excitability In Progressive Myoclonus Epilepsies (PME), By Means Of Polygraphic Techniques And
Transcranial Magnetic Stimulation (TMS). Methods: 12 Patients With PME And 8 Normal Subjects Were Investigated. TMS Was
Performed By Delivering Paired Magnetic Stimuli At Interstimulus Interval (ISI) Ranging From 50 To 200 Msec And At Stimulus Intensity
Of 10% Above Threshold. Modulation Of The Area Of The Test Motor Evoked Potential (MEP) Was Expressed As Percentage Of
Conditioning MEP (100%). EEG-EMG Correlation Was Performed In 1000 Msec Epochs By Means Of A 21 -channel Computerized
Polygraphic System.

Paired TMS Showed A Significant Facilitation (p)

Our Data Demonstrate, In PME, An Increased Excitability Of The Motor System, Occurring At A Supraspinal, Cortical Level.




em Psiquiatría