Double-blind controlled investigation of bilateral prefrontal transcranial magnetic stimulation for the treatment of resistant major depression.
Loo CK, Mitchell PB, Croker VM, Malhi GS, Wen W, Gandevia SC, Sachdev PS.
Psychol Med. 2003 Jan;33(1):33-40. Comment in:Psychol Med. 2003 Jan;33(1):7-13.

Department of Psychiatry, Mood Disorders Unit, Black Dog Institute and
Neuropsychiatric Institute, Prince of Wales Hospital, School of Psychiatry,
University of New South Wales, Randwick, Australia.

BACKGROUND: The efficacy and safety of bilateral prefrontal repetitive
transcranial magnetic stimulation (rTMS) for treating resistant major depression
were examined in a double-blind, placebo-controlled study. METHOD: Nineteen
medication-resistant depressed subjects were randomly assigned to 3 weeks of
active or sham rTMS. Effects on mood and neuropsychological function were
assessed. RESULTS: Both groups improved significantly in mood over the 3 weeks,
but there was no significant difference between active and sham treatments.
There were no significant neuropsychological effects. CONCLUSIONS: Bilateral
rTMS was not superior to sham in treating resistant depression in this pilot
study, but caused no neuropsychological impairment.




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